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近20年中药注射液在心力衰竭研究领域的可视化分析

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摘要:

目的 对近20年中药注射液在心力衰竭研究方面的文献进行可视化分析,探索中药注射液
在该领域的发展趋势、研究热点及前沿动向。方法 利用CiteSpace软件对CNKI数据库符合研究主题的中
文文献绘制作者、研究机构、关键词知识图谱,进行可视化分析。结果 2259篇文献纳入本次研究,平
均每年发文约113篇;涉及作者4588名,形成以毛静远、胡志希、谢雁鸣为代表的作者合作网络;2368
所研究机构中天津中医药大学第一附属医院、天津中医药大学、中国人民大学统计学院、中国中医科
学院中医临床基础医学研究所在共现网络中占据重要地位;661个关键词中心力衰竭、心功能、临床观
察、冠心病、脑钠肽位于前5位,关键词聚类节点数大于10的有12类,得到16个突显关键词。结论 该研
究领域团队内部合作相对密切,但团队间合作欠佳。研究热点多集中于中药注射液联合其他药物对心力
衰竭的临床疗效观察、系统评价及动物实验对代谢组学、药动学的探索。联合用药左西孟旦、心功能、
系统评价、安全性、高血压心衰可能是是中药注射液在心力衰竭研究中的前沿与发展方向。

Abstract:

Objective To give a visual analysis on literature related to research field of Chinese herbal
injections in treating heart failure (HF) in past 20 years, and investigate the development tendency, research
hotspots and frontier trends in this field. Methods CiteSpace software was used to draw knowledge graphs of
authors, research institutions, and keywords in Chinese literature matching the research topics in CNKI databases,
and give a visual analysis. Results There were 2259 documents included in the study, and there were 113 papers
published averagely per year. There were 4588 authors involved, forming an author cooperative network represented
by Mao Jingyuan, Hu Zhixi, and Xie Yanming. Among 2368 research institutions, the First Affiliated Hospital of
Tianjin University of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, School
of Statistics of Renmin University of China and Institute of Chinese Basic Clinical Medicine of China Academy of
Chinese Medical Sciences took up important positions in the co-occurrence network. In 661 keywords, heart failure
(HF), heart function, clinical observation, coronary heart disease (CHD) and brain natriuretic peptide (BNP) were in
the top 5. There were 12 categories with the number of keyword clustering nodes more than 10, and there were 16
highlight keywords obtained. Conclusion The internal cooperation is relatively close within a team in this research
field but the inter- team cooperation is poor. The research hotspots of Chinese medicine injections combined
with other drugs in treating heart failure are mostly focused on clinical efficacy observation, systematic evaluation
and explorations on metabolomics and pharmacokinetics in animal experiments. The Chinese medicine injections
combined with levosimendan, heart function, systematic evaluation, safety and hypertensive heart failure may be the
frontier and development direction in this field.

基金项目:

北京中医药大学新教师启动基金项目(2019-JYBXJSJJ045)

参考文献:

  • 2008

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