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血清PⅢNP、Apelin及hs-CRP/PAB比值在心衰并发心律失常中对预后评估的价值

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摘要:

目的 探讨血清Ⅲ型前胶原氨基端肽(PⅢNP)、脂肪因子(Apelin)及超敏C反应蛋白
/前清蛋白(hs-CRP/PAB)比值在心力衰竭(心衰)并发心律失常对临床预后评估的价值。方法 选择
2019年1月至2022年1月于北京民航总医院心内科治疗的115例心衰患者进行研究,其中合并心律失常者
为病例组(n=55),未并发心律失常者作为对照组(n=60),分析两组患者的血清PⅢNP、Apelin及
hs-CRP/PAB比值水平变化情况及其对预后的预测价值。结果 病例组血清PⅢNP及hs-CRP/PAB比值水
平显著高于对照组,Apelin显著低于对照组,差异具有统计学意义(P<0.05);预后不良组血清PⅢNP
及hs-CRP/PAB比值水平显著高于预后良好组,Apelin显著低于预后良好组,差异具有统计学意义(P
<0.05);ROC结果显示,血清PⅢNP预测心衰并发心律失常预后的AUC为0.749,灵敏度为81.15%,
特异度为87.18%,截断值为121.98 pg/L;血清Apelin预测心衰并发心律失常预后的AUC为0.822,灵敏度
82.56%,特异度为88.69%,截断值为2.03 ng/ml。血清hs-CRP/PAB比值预测心衰并发心律失常预后的
AUC为0.888,灵敏度为88.45%,特异度为90.16%,截断值为3.05。结论 血清PⅢNP、Apelin及hs-CRP/
PAB比值在心衰并发心律失常患者中异常表达,对其预后具有一定评估价值。

Abstract:

Objective To investigate the value of serum type Ⅲ procollagen N-terminal peptide (PⅢ
NP), adipokine (Apelin) and ratio of high sensitivity C-reactive protein to prealbumin (hs-CRP/PAB) to clinical
prognosis reviewing in patients with heart failure (HF) complicated by arrhythmia. Methods HF patients (n=115)
were chosen from Department of Cardiology in Civil Aviation General Hospital from Jan. 2019 to Jan. 2022, and
divided into case group (with arrhythmia, n=55) and control group (without arrhythmia, n=60). The changes of
serum PⅢNP, Apelin and hs-CRP/PAB were observed and their value to prognosis prediction was analyzed in 2
groups. Results The levels of serum PⅢNP and hs-CRP/PAB were significantly higher, and Apelin level was
significantly lower in case group than those in control group (P<0.05). The levels of serum PⅢNP and hs-CRP/
PAB were significantly higher, and Apelin level was significantly lower in the patients with poor prognosis than
those in patients with good prognosis (P<0.05). The results of ROC curve analysis showed that the AUC of PⅢ
NP in predicting prognosis was 0.749, sensitivity was 81.15%, specificity was 87.18% and cutoff value was 121.98
pg/L. The AUC of Apelin was 0.822, sensitivity was 82.56%, specificity was 88.69%, and cutoff value was 2.03
ng/mL. The AUC of hs-CRP/PAB was 0.888, sensitivity was 88.45%, specificity was 90.16%, and cutoff value was
3.05. Conclusion The expressions of serum PⅢNP, Apelin and hs-CRP/PAB are abnormal in patients with HF
complicated by arrhythmia, which has some review value to prognosis.

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